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Zyloprim can substantially reduce serum and urinary uric acid levels in previously refractory patients even in the presence of renal damage serious enough to render uricosuric drugs virtually ineffectiveSalicylates may be given conjointly for their antirheumatic effect without compromising the action of ZyloprimThis is in contrast to the nullifying effect of salicylates on uricosuric drugs.

Hyperuricemia may be primaryas in goutor secondary to diseases such as acute and chronic leukemiapolycythemia veramultiple myelomaand psoriasisIt may occur with the use of diuretic agentsduring renal dialysisin the presence of renal damageduring starvation or reducing dietsand in the treatment of neoplastic disease where rapid resolution of tissue masses may occurAsymptomatic hyperuricemia is not an indication for treatment with Zyloprimsee INDICATIONS AND USAGE

In patients with pre-existing liver diseaseperiodic liver function tests are recommended during the early stages of therapysee WARNINGS

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